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It treats muscle spasms which may occur in diseases affecting the nervous system, such as cerebral palsy, multiple sclerosis, motor neuron disease, or due to a disease or injury of head, brain, or spine.
What is tizanidine-oral, and how does it work mechanism of action? Tizanidine is a skeletal muscle relaxant. It works on alpha2 receptors in the central nervous system brain and spinal cord and blocks nerve impulses from reaching muscles which produces muscle relaxation. The FDA approved tizanidine in November Is tizanidine-oral available as a generic drug? What are the uses for tizanidine-oral? Tizanidine is used for the treatment and management of skeletal muscle spasticity.
In general, muscle relaxants should be used temporarily eg, for a few days or intermittently for a few days when needed Ref. Note: For muscle spasticity due to neurologic injury or disease eg, multiple sclerosis, stroke, spinal cord injury, traumatic brain injury, amyotrophic lateral sclerosis ALS Ref. In the treatment of spasticity associated with stroke eg, hemiplegic shoulder pain, some experts initiate therapy with 2 mg every 8 hours as needed Ref. The renal dosing recommendations are based upon the best available evidence and clinical expertise. Altered kidney function: Oral
Common side effects include dry mouth, sleepiness, weakness, and dizziness. Tizanidine has been found to be as effective as other antispasmodic drugs and is more tolerable than baclofen and. Side effects include dizziness, drowsiness, weakness, nervousness, hallucinations, depression, vomiting, dry mouth, constipation, diarrhea, stomach pain, heartburn, increased muscle spasms, back pain, rash, sweating, and a tingling sensation in the arms, legs, hands, and feet. It has a volume of distribution of 2. From Wikipedia, the free encyclopedia. By mouth tablets, capsules.
Tizanidine is used to help relax certain muscles in your body. It relieves spasms, cramping, and tightness of the muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine. Tizanidine does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition. Tizanidine acts on the central nervous system CNS to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects.
It works by slowing the central nervous system to allow muscles to relax. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Authored by Roger Weiss, MD. Tizanidine pill is a smooth muscle zanaflex 2 mg oral tablet indicated for the treatment of muscle spasticity and immobility associated with strains. If prescribed, one must understand how to identify Zanaflex, and properly use it as dosed. Some Tizanidine tablets are scored and the capsules might be presented in two different colors. There are many reasons why being able to identify Tizanidine pills is important.
The dose can be repeated at 6—8 hour intervals, as needed, to a maximum of three doses in 24 hours. Gradually increase the dose by 2—4 mg at zanaflex 2 mg oral tablet dose, with 1—4 days in between dose increases until satisfactory reduction in muscle tone is achieved. In geriatric patients, individual doses should be reduced during titration. If a geriatric patient requires higher doses, increase individual doses, rather than dosing frequency. Due to the potential for hepatotoxicity, monitoring of aminotransferase levels is recommended at baseline and 1 month after maximum dose is achieved, or if hepatic injury is suspected. Tizanidine should be administered consistently with or without food.
Tizanidine is a short-acting drug that asacol buy taken only as needed. Your healthcare provider may gradually increase this amount as needed The recommended starting dosage of Zanaflex is 4 mg every six to eight hours. Between the generics, tizanidine is more expensive than cyclobenzaprine. Patients rated Zanaflex 3. I was given samples of Zanaflex 4mg capsules by my PM dr. Each dose of tizanidine only lasts between three and six hours, with a peak in effectiveness happening about one or two hours after taking it.
Structurally, tizanidine is similar to clonidine, but only to as potent for lowering blood pressure. Elliott, in Current Therapy in Pain, Tizanidine had been used predominantly in the management of spasticity; however, it has also proved useful for a variety of painful conditions. As to its efficacy in the management of spasticity, tizanidine compares favorably with zanaflex 2 mg oral tablet baclofen and and seems to cause less muscle weakness than baclofen and a lower incidence of sedation than. It appears that muscle strength is fairly well preserved in patients taking tizanidine for spasticity or muscle spasm, because less weakness is associated with use of this drug compared with baclofen or.