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Singulair Tablet is an anti-allergic medicine used for the treatment of asthma and other allergic conditions such as a runny or blocked nose, watery eyes, itching, etc. It contains montelukast as its. This medicine works by inhibiting the action of natural chemical substance leukotrienes responsible for allergic conditions.
However, your pharmacist may have suggested a different schedule that is more appropriate for you. Do not use more of this product, or more often, than prescribed. It must be used regularly and continuously to maintain its beneficial effects.
This medicine is used in the management of mild to moderate asthma. Also used to treat bronchoconstriction tightening of muscles in the lungs caused by exercise. Some patients might experience stomach pain, headache, thirst, or seizures.
The originating document has been archived. Do not pass it on to others. Leukotrienes sumycin 250mg narrowing and swelling of airways in the lungs. Asthma is a long-term disease.
If taking montelukast for another indication, do not take additional dose to prevent exercise-induced bronchospasm EIB. Psychiatric: Agitation, including aggressive behavior or hostility, anxiousness, depression, disorientation, dream abnormalities, hallucinations, insomnia, tic, irritability, restlessness, somnambulism, suicidal thinking and behavior including suicide, tremor, obsessive compulsive disorders. Inhaled corticosteroid may be reduced gradually; do not abruptly substitute montelukast for inhaled or singulair 4mg tablet corticosteroids. Patients with known aspirin sensitivity should continue to avoid aspirin or nonsteroidal anti-inflammatory drugs NSAIDs while taking montelukast; not to be given for treatment of bronchoconstriction resulting from aspirin or NSAID intake. Blocks binding of leukotriene D4 to its receptor; alters pathophysiology associated with inflammatory process that contributes to signs and symptoms of asthma.
This leaflet has been written for parents and carers about how to use this medicine in children. Montelukast blocks the effects of chemicals in the body that cause inflammation and narrowing of the airway. Taking montelukast regularly will help to stop your child from having asthma attacks. Your doctor will work out the amount of montelukast the dose that is right for your child. Tablets should be swallowed whole, with a glass of water, juice or milk.
All medicines have risks and benefits. It also prevents the narrowing of airways triggered by exercise. Symptoms of asthma include coughing, wheezing and chest tightness. Not all people with asthma wheeze.
Montelukast is a long term-controller medication which should not be substituted for short acting beta-agonists. Complete abrupt removal of beclomethasone in patients receiving both treatments caused clinical deterioration in some patients, suggesting that tapering inhaled corticosteroids as tolerated rather than abrupt removal of steroids is preferred.
Based on further in vitro results in human liver microsomes, therapeutic plasma concentrations of montelukast do not inhibit cytochromes P 3A4, 2C9, 1A2, 2A6, 2C19, or 2D6. Patients should be advised to have appropriate rescue medication available. The oral bioavailability and C max are not influenced by a standard meal. Chronic Toxicity: The toxic potential of montelukast sodium was evaluated in a series of repeated dose toxicity studies of up to 53 weeks in monkeys and rats and up to 14 weeks in infant monkeys and in mice.
Montelukast is a potent, orally active compound that significantly improves parameters of asthmatic inflammation. Characteristics in Patients: Gender: The pharmacokinetics of montelukast are similar in males and females. There were no findings that would preclude administration at the therapeutic dosage level for both adults and pediatric patients.
For allergic rhinitis, the time of administration may be individualized to suit patient needs. Protection was consistent throughout the week treatment period, indicating that tolerance did not occur. Efficacy can be extrapolated from clinical data in adults. For the mg film-coated tablet, the mean peak plasma concentration C max is achieved 3 hours T max after administration in adults in the fasted state.
In a separate crossover study, protection was observed after two once-daily doses. The incidence of thirst was not significantly different in the two treatment groups. Montelukast sodium was negative in the in vitro microbial mutagenesis assay and the V mammalian cell mutagenesis assays, with and without metabolic activation. Distributor: Zuellig Pharma. Use in children 2 - 14 years of age for seasonal allergic rhinitis may be considered based on demonstrated safety yasmin cost this age group, although efficacy has not been demonstrated in clinical trials.
Your doctor will prescribe a reliever inhaler for you to use in case you have an asthma attack. Make sure that you keep it with you all the time. The singulair 4mg tablet common side-effects of montelukast are respiratory infections, tummy abdominal pain and headache. Asthma is a common condition caused by inflammation in the smaller airways of the lungs. The inflammation irritates the muscles around the airways and causes them to constrict.
Montelukast Sodium Available Brands. Ad-din Pharmaceuticals Ltd. Al-Madina Pharmaceuticals Ltd. Amulet Pharmaceuticals Ltd.
Safety and effectiveness in pediatric singulair 4mg tablets less than 12 months of age with asthma have not been established. There have been no clinical trials in patients with asthma to evaluate the relative efficacy of morning versus evening dosing. The pharmacokinetics of montelukast are similar whether dosed in the morning or evening.
Montelukast may cause serious or life-threatening mental health changes while you are taking this medication or after treatment has stopped. Tell your doctor if you have or have ever had any type of mental illness. However, you should know that it is possible to develop these changes in mental health and behavior even if you have never had any mental health problems in the past. Montelukast is used to prevent wheezing, difficulty breathing, chest tightness, and coughing caused by asthma in adults and children 12 months of age and older.
What Singulair Paediatric is and what it is used for 2. What you need to know before your child takes Singulair Paediatric 3. How to take Singulair Paediatric 4. By blocking leukotrienes, Singulair Paediatric improves asthma symptoms and helps control asthma.
Unlike most allergy medications, Singulair doesn't usually cause drowsiness or sedation, which may make it a good choice for children who have gotten sleepy with Zyrtec, Claritin, or Clarinex. Singulair is approved by the U. Children should not take Singulair for the immediate relief of an asthma attack.
Authored by Dr. Javier P Berrios, MD