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Divalproex sodium, the active drug in Depakote and Depakote ER, is widely used for helping prevent migraine. Both drug were used in the maintenance of Bipolar mood disorder not in Unipolar Depression.
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Depakote is used to help treat certain psychiatric conditions and convulsions. Not valid at any other pharmacy. Walmart cards must be used at Walmart pharmacies. Prices for some drugs may be higher or vary in some states including, but not necessarily limited to, CA and MN. Walgreens cards must be used at Walgreens pharmacies. It is used to help treat certain psychiatric conditions and convulsions. Depakote is also used to relieve migraines.
These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Drug Exclusivity Exclusivity is the sole marketing rights granted by the FDA to a manufacturer upon the approval of a drug and may run simultaneously with a patent. Exclusivity periods can run from days to seven years depending upon the circumstance of the exclusivity grant. AB Products meeting necessary bioequivalence requirements. Multisource drug products listed under the same heading i. Two or more reference listed drugs are generally selected only when there are at least two potential reference drug products which are not bioequivalent to each other. Fatty acid derivative anticonvulsants.
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What is valproic acid, and how does it work mechanism of action? Valproic acid and its derivative, divalproex, are oral drugs that are used for the treatment of convulsions, migraines and bipolar disorder. The active ingredient in both products is valproic acid. Divalproex is converted to valproic acid in the stomach. Scientists do not know the mechanism of action of valproic acid.
Hepatic failure resulting in fatalities has occurred in patients receiving valproate and its derivatives. These incidents usually have occurred during the first six months of treatment. Serious or fatal hepatotoxicity may be preceded by non-specific symptoms such as malaise, weakness, lethargy, facial edema, anorexia, and vomiting. In patients with epilepsy, a loss of seizure control may also occur. Patients should be monitored closely for appearance of these symptoms.
Valproic acid and its analogs are hepatotoxic and are contraindicated in patients with hepatic disease or significant hepatic dysfunction. Use with extreme caution in patients with a prior history of hepatic disease. Hepatotoxicity, including hepatic failure, has been fatal and may more commonly occur in the first 6 months of treatment. Because carnitine deficiency may promote hepatotoxicity, valproate should be avoided in patients with depakote generic cheap errors of carnitine metabolism. Clinicians should not completely rely on serum biochemistry since these LFTs may not always be abnormal, but should also consider the results of a detailed medical history and physical examination.