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Like other SSRIs, citalopram lowers the level of serotonin that neurons reabsorb, which results in more free serotonin in the brain. For some, this can ease their symptoms of anxiety and depression. Monoamine oxidase inhibitors MAOIs, such as linezolid, phenelzine, etc, increase the risk of serotonin syndrome, a mild to life-threatening build up of serotonin in the system. Similarly, escitalopram can interact with other agents that affect serotonin in the brain, such as tricyclic antidepressants, certain pain medications, supplements that contain St.

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