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Overactive bladder syndrome OAB is a common medical condition that has a significant impact on the quality of life in women. Furthermore, the incidence of OAB increases with age. Urge incontinence causes more distress to patients than does stress incontinence. Apart from specific non-pharmacological treatments that have variable responses, the mainstay of current pharmacological treatment involves the use of muscarinic receptor antagonists. The overall therapeutic effectiveness of muscarinic receptor antagonists is limited by a combination of limited efficacy and troublesome side effects.
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Oxybutynin, via an anticholinergic effect, relaxes the detrusor muscle of the bladder. The patch avoids first-pass metabolism in the liver, reducing the active metabolite N-desethyloxybutynin, the main cause of dry mouth.
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Overactive bladder is a clinical syndrome characterized by one or more symptoms of urgency a difficult-to-defer need to urinate, frequency greater than eight urinations per 24 hours, nocturia, and incontinence. In persons without overactive bladder, the need to empty the bladder becomes progressively more demanding; in overactive bladder, urgency is characterized by unheralded messages of an immediate need to empty the bladder.
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