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When constituted as directed, each bottle will contain mL of a suspension providing the equivalent of mg of linezolid per each 5 mL. Zyvox cost of generic sinemet a medication used to treat infections. Zyvox is available as a brand name or generic drug and comes as an IV injection, an oral liquid and an oral tablet.

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We analysed data on an endpoint basis for continuous outcomes e. This syndrome is an allergic reaction characterised by the flushing of the upper body, with itching due to histamine release Sivagnanam Several studies have compared linezolid with vancomycin; the outcomes were inconsistent. The treatment allocation was not concealed in the remaining seven studies Itani ; Kohno ; Sharpe ; Stevens ; Weigelt ; Wilcox ; Yogev So we assumed that none of the included trials undertook ITT analyses.

There were baseline imbalances in two trials: in Stevens, participants in the linezolid group were significantly older than those in the vancomycin group These two trials were judged to be at an high risk of bias for this domain. Exclusion of studies with inadequate concealment of allocation. We completed a risk of bias table for each eligible study. We included people of any age or gender presenting with skin and soft tissue infections e. We presented dichotomous outcomes e. There were fewer incidents of red man syndrome RR 0.

For Weigelt, however, the mean treatment duration was longer for the linezolid group than for the vancomycin group MD 0. Anacin buy 100 compared with vancomycin alone. Overall, two of the nine RCTs adequately addressed incomplete outcome data, and had a low dropout rate Lin ; Weigelt We searched, but did not find the protocols for the other included trials, and so the remaining eight RCTs were judged to be at unclear risk of bias. Fewer people in the linezolid group suffered from red man syndrome, pruritus and rash compared with vancomycin, but more people in the linezolid group suffered from thrombocytopenia and nausea.

Linezolid has a unique mechanism of action. Linezolid and vancomycin are antibiotics that are effective in treating skin and soft tissue infections, particularly infections caused by bacteria that have developed resistance to some antibiotics. It stops the growth and reproduction of bacteria by disrupting translation of messenger RNA into proteins in the ribosome. Of these, thirteen articles were multiple publications, in which nine articles relate to four trials Lin ; Stevens ; Weigelt ; Yogev Other five papers Itani ; Jaksic ; Kohno ; Sharpe ; Wilcox were not multiple publications and referred to one trial each.

Treatment allocation was not concealed in seven of the trials and it was unclear whether it had been in the remaining two RCTs. See the Characteristics of included studies and Characteristics of excluded studies tables.

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