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UK, remember your settings and improve government services. Indication restricted to nausea and vomiting, new contraindications, and reduced dose and duration of use. A higher risk was observed particularly in people older than 60 years, people taking daily oral domperidone doses of more than 30 mg, and those taking QT-prolonging medicines or CYP3A4 inhibitors at the same time as domperidone. For indications other than nausea and vomiting, the benefits were not considered to outweigh the cardiac risk. Domperidone use in children is under further investigation. Letter sent to healthcare professionals on 25 April
Though not considered or discussed in this document, this advisory may undermine success for mother-baby dyads struggling to successfully breastfeed. The use of domperidone for breastfeeding problems is common practice among lactation physicians across Canada. Without the availability of this medication, I suspect that a significant number of mothers will fall short of achieving their breastfeeding goals. The starting dose is 90 mg per day and I sometimes bump up the dose to as high as to mg per day — 5x the maximum recommended dose in the advisory! In fact this prescribing practice is standard of care among Canadian lactation specialists — with some variation from clinic to clinic.
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