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HRT stands for hormone replacement therapy. For transfeminine people, this usually means trying to replicate the hormones found in cisgender women. People who are assigned male at birth AMAB will have higher testosterone levels and lower estradiol estrogen levels compared to those assigned female at birth AFAB. The purpose of HRT is to decrease testosterone levels and raise estradiol levels to levels comparable to that of healthy cis females. This is usually accomplished using antiandrogens blocks testosterone and prevents masculinization and estradiol causes feminization. Estradiol is the main human female sex hormone, and is a type of estrogen. Estradiol is later metabolized by your body into esterone E1 and estriol E3, and these are optional blood tests that you can get, but aren't necessary.

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Premarin Conjugated Estrogens vaginal cream belongs to the class of medications known as estrogen replacement therapy. Premarin Vaginal cream is used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse. Premarin Vaginal cream should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions. This medication can harm an unborn baby or cause birth defects. Do not use this medication if you are pregnant. Premarin Vaginal may also slow breast milk production.

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