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Premarin is a medication that is prescribed for women suffering from different symptoms of menopause, including hot flashes, burning, vaginal dryness and irritation.
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Objectives: To determine the relative bioavailability of the estrogenic components of a generic brand of conjugated estrogens marketed in Chile in comparison to that of Conpremin Premarin in the United States. Methods: A randomized cross-over study was conducted on 16 healthy postmenopausal women receiving single oral doses of either two Conpremin 0. A gas chromatography tandem mass spectrometry assay was used to determine estrogen components. Results: The peak plasma concentrations of unconjugated and total estrone and equilin, unconjugated 17 beta-dihydroequilin and 17 beta-estradiol were higher and occurred earlier with the generic conjugated estrogens than with Conpremin. Additionally, no measurable plasma concentration of unconjugated delta 8,9-dehydroestrone or 17 beta-delta 8,9-dehydroestradiol was seen after administration of the generic conjugated estrogens. Conclusions: These pharmacokinetic results indicate that the generic tablets do not have the modified-release characteristics of Conpremin tablets.
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Why is Premarin prescribed? Premarin is a hormone, a substance produced by the body. It is needed for normal growth and development of female sex organs and for functions such as bearing children. Premarin is used for symptoms associated with menopause: hot flashes feelings of warmth in the face, neck, and chest, sweating, sleep disturbance, vaginal discomfort dryness and itchiness, poor concentration, and irritability. It also is used in the treatment of breast cancer in postmenopausal women and breast and prostate cancer in men. Premarin also is used with diet, calcium supplements, and exercise to slow the progression of osteoporosis, a disease common in women after menopause resulting in bones that break easily.