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Class III calcium channel blockers are intermediate in action affecting calcium ion channels in both cardiac muscle cells and smooth muscle cells in blood vessels. The effect of this is to combine a reduction in heart rate with a fall in blood pressure and they are useful in treating angina and hypertension.
Prostaglandins play a role in pain by sensitising sensory nerve endings to the effects of other mediators such as bradykinin. Thromboxanes promote platelet aggregation.
They are made up of three subunits one of which activity. When a neurotransmitter or hormone binds with its receptor, the α subunit of the G-protein combined with GTP detaches and activates an effector in the cell.
Authored by Dr. Linda Suriyakham, PHD