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Exacerbation of angina and, in some cases, myocardial infarction occurrence after abrupt discontinuance. When discontinuing long-term administration of beta blockers particularly with ischemic heart disease, gradually reduce dose over weeks and carefully monitor. If angina markedly worsens or acute coronary insufficiency develops, reinstate beta-blocker administration promptly, at least temporarily in addition to other measures appropriate for unstable angina. Warn patients against interruption or discontinuance of beta-blocker therapy without physician advice. Because coronary artery disease is common and may be unrecognized, slowly discontinue beta-blocker therapy, even in patients treated only for hypertension. Long-term beta blocker therapy should not be routinely discontinued before major surgery; however, the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures.


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These medicines are often used to treat high blood pressure when other medicines have not worked. Beta blockers are medicines that lower blood pressure. The medicines block the effects of the hormone epinephrine, also known as adrenaline. Beta blockers cause the heart to beat more slowly and with less force. This lowers blood pressure.

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