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The most frequently prescribed stimulants as of were lisdexamfetamine, methylphenidate, and amphetamine. Stimulants in therapeutic doses, such as those given to patients with ADHD, increases ability to focus, vigor, sociability, libido and may elevate mood. However, in higher doses stimulants may actually decrease the ability to focus, a principle of the Yerkes-Dodson Law. In higher doses stimulants may also produce euphoria, vigor, and decrease need for sleep. Many, but not all, stimulants have ergogenic effects.

The current study utilizing the FAERS database revealed that amiodarone was significantly associated with increased risk of hyperthyroidism, hypothyroidism, interstitial lung disease, and hepatic disorders, which are serious amiodarone-induced adverse events that are well recognized in clinical practice, and indicated that the FAERS analysis was able to detect the risk of amiodarone-induced adverse events. In addition, our analyses also detected significant associations between certain antidiabetic drugs and adverse events Table 2. However, diabetic patients have a high incidence of thyroid dysfunction and hepatic disorders 23, 24; thus, the association between antidiabetic drugs and thyroid dysfunction and hepatic disorders are uncertain. The associations between antidiabetic drugs and the adverse events identified in the current study might be attributable to confounding effects. Meanwhile, the association between diabetes mellitus and interstitial lung disease was unknown.

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