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The number of individuals affected by psychostimulant use disorder PSUD has increased rapidly over the last few decades resulting in economic, emotional, and physical burdens on our society. Modafinil MOD, which is approved for clinical use for the treatment of narcolepsy and sleep disorders, blocks DAT just like commonly abused psychostimulants. While illicit drugs have long been a societal concern, drug use rates have been growing in recent years. Globally, stimulants such as cocaine and amphetamines are used by approximately 0.

It is used for the treatment of Narcolepsy in adult patients. Narcolepsy can be defined as a rare long-term neural condition in which the sleep-regulating mechanism of the brain is altered. Narcolepsy can lead to excessive daytime sleepiness, lack of concentration, sleep attacks suddenly falling asleep, cataplexy temporary loss of muscle modafinil 10mg price leading to weakness and falling, sleep paralysis it is a temporary inability to move or speak during waking up or falling asleep, excessive dreaming and waking in the middle of the night. Specific serious side effects may include depression, aggression or hostility towards other people or suicidal thoughts or other changes in your behaviour. Consult your doctor immediately if you experience any such side effects.

If you have a sleep disorder, certain medications can help you feel more awake. These drugs do not cure these sleep disorders, nor do they take the place of getting enough sleep. Nuvigil and Provigil are very similar drugs with few differences. This article compares them to help you decide if one drug might be better for you. Nuvigil armodafinil and Provigil modafinil boost brain activity to stimulate certain brain areas that are involved in wakefulness.

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There are no factors that are known to predict the risk of occurrence or the severity of multiorgan hypersensitivity reactions associated with modafinil. Other associated manifestations included myocarditis, hepatitis, liver function test abnormalities, hematological abnormalities e. Because multiorgan hypersensitivity is variable in its expression, other organ system symptoms and signs, not noted here, may occur.

If a multiorgan hypersensitivity reaction is suspected, modafinil should be discontinued. Persistent Sleepiness Patients with abnormal levels of sleepiness who take modafinil should be advised that their level of wakefulness may not return to normal. Patients with excessive sleepiness, including those taking modafinil, should be frequently reassessed for their degree of sleepiness and, if appropriate, advised to avoid driving or any other potentially dangerous activity.

Prescribers should also be aware that patients may not acknowledge sleepiness or drowsiness until directly questioned about drowsiness or sleepiness during specific activities. Postmarketing adverse events associated with the use of modafinil have included mania, delusions, hallucinations, suicidal ideation and aggression, some resulting in hospitalization. Many, but not all, patients had a prior psychiatric history. One healthy male volunteer developed ideas of reference, paranoid delusions, and auditory hallucinations in association with multiple daily mg doses of modafinil and sleep deprivation.

There was no evidence of psychosis 36 hours after drug discontinuation. Caution should be exercised when modafinil is given to patients with a history of psychosis, depression, or mania. Consideration should be given to the possible emergence or exacerbation of psychiatric symptoms in patients treated with modafinil.

If psychiatric symptoms develop in association with modafinil administration, consider discontinuing modafinil. Such an evaluation usually consists of a complete history and physical examination, and it may be supplemented with testing in a laboratory setting. Some patients may have more than one sleep disorder contributing to their excessive sleepiness e. Cardiovascular System Modafinil has not been evaluated in patients with a recent history of myocardial infarction or unstable angina, and such patients should be treated with caution.

In clinical studies of modafinil, signs and symptoms including chest pain, palpitations, dyspnea and transient ischemic T-wave changes on ECG were observed in three subjects in association with mitral valve prolapse or left ventricular hypertrophy. It is recommended that modafinil tablets not be used in patients with a history of left ventricular hypertrophy or in patients with mitral valve prolapse who have experienced the mitral valve prolapse syndrome when previously receiving CNS stimulants.

Such signs may include but are not limited to ischemic ECG changes, chest pain, or arrhythmia. If new onset of any of these symptoms occurs, consider cardiac evaluation. The differential use was slightly larger when only studies in OSA were included, with 3. Increased monitoring of blood pressure may be appropriate in patients on modafinil. Patients Using Steroidal Contraceptives The effectiveness of steroidal contraceptives may be reduced when used with modafinil tablets and for one month after discontinuation of therapy.

Alternative or concomitant methods of contraception are recommended for patients treated with modafinil tablets, and for one month after discontinuation of modafinil. Patients Using Cyclosporine The blood levels of cyclosporine may be reduced when used with modafinil. Monitoring of circulating cyclosporine concentrations and appropriate dosage adjustment for cyclosporine should be considered when these drugs are used concomitantly.

Patients with Severe Hepatic Impairment In patients with severe hepatic impairment, with or without cirrhosis, modafinil should be administered at a reduced dose. Elderly Patients In elderly patients, elimination of modafinil and its metabolites may be reduced as a consequence of aging.

WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Common adverse reactions include rash, nausea, dizziness, headache, insomnia, anxiety, feeling nervous. Modafinil should be taken as a single dose in the morning. If continuous positive airway pressure CPAP is the treatment of choice for a patient, a maximal effort to treat with CPAP for an adequate period of time should be made prior to initiating modafinil.

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