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First, let's talk about the background of the drug itself. Modafinil is a eugeroic, a wakefulness-promoting agent, and traces its roots back to adrafinil, invented in by French chemists. They found that it produces hyperactivity in mice, leading to an interest in using it as a treatment for sleep disorders. Modafinil was identified as the active part of adrafinil and was subsequently isolated and trialled in the 90s. The drug is believed to work by inhibiting dopamine uptake, leading to increased dopamine levels in the brain.

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They found 24 studies dealing with different benefits associated with taking modafinil, including planning and decision making, flexibility, learning and memory, and creativity. What emerged was that the longer and more complex the task tested, the more consistently modafinil conferred cognitive benefits. Modafinil made no difference to working memory, or flexibility of thought, but did improve decision-making and planning. Interestingly, we found that the type of test used to assess modafinil's cognitive buys provigil uk online has changed over the last few decades. In contrast, more recent studies have, in general, used more complex tests: when these are used, it appears that modafinil more reliably enhances cognition: in particular 'higher' brain functions that rely on contribution from multiple simple cognitive processes. Anna-Katharine Brem, a researcher at both the University of Oxford and Harvard Medical School, said: 'We ended up having two main conclusions: first, that, in the face of vanishingly few side effects in these controlled environments, modafinil can be considered a cognitive enhancer; and, second that we need to figure out better ways of testing normal or even supra-normal cognition in a reliable manner.

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