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Avissar-Whiting noted that the concerns were first raised by Jack Lawrence, a British medical student, according to The Guardian. The study was one of the largest ivermectin trials in the world, and has been included in two recent meta-analyses Bryant et al. Some have questioned whether the positive conclusions of those meta-analyses would still stand when the Egyptian study is removed. It also found that those who received ivermectin required invasive ventilation sooner than those on placebo. That conclusion started to fall apart when Lawrence took on a medical school assignment that had him look deeper into the paper. Lawrence also found that the raw data, which are available online for purchase, contradicted the study on several occasions. Gideon Meyerowitz-Katz, an epidemiologist from the University of Wollongong in Australia, also highlighted some of those discrepancies in a Medium post. There are multiple ongoing phase III randomized controlled trials that will likely provide more definitive results on ivermectin, including Boulware's study and the U.

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Ivermectin was discovered in and came into medical use in It was developed, primarily, to treat parasitic infections which were difficult to treat with other anti-parasitics. To keep the worms at bay, ivermectin is given at least once per year for the 10—year lifespan of the adult worms. Ivermectin is also used to treat infection with parasitic arthropods. For most scabies cases, ivermectin is used in a two dose regimen: a first dose kills the active mites, but not their eggs.