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Before Mectizan, the only safe and effective intervention for river blindness was purchase mectizan generic control, achieved by aerial larviciding of the rivers where the blackflies that transmit the disease breed. In the late s, Nobel laureate Dr. Campbell, another MRL researcher, Dr. Mohammed Aziz, championed the clinical development of Mectizan. Aziz led the collaboration with WHO in the early s to design and implement field studies in West Africa that ultimately proved the effectiveness of the drug against river blindness. In Yemen and African countries where river blindness and LF are co-endemic, DEC is not considered a safe treatment due to its potential for severe ocular side effects.

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