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Oral dosing may be more convenient in institutional outbreaks and in the treatment of mentally impaired patients. Ivermectin has been used extensively and safely in the treatment of other parasitic infections, but the U. Food and Drug Administration has not approved the drug for the treatment of scabies infection. The safety of oral ivermectin in pregnant and lactating women and young children has yet to be established. Scabies is a skin disease caused by infestation with the mite Sarcoptes scabiei.

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Oral ivermectin appears to be effective for treating people with classical or crusted scabies. Transient exacerbation of pruritus may occur at the beginning of treatment. Ivermectin has been used globally in the treatment of onchocerciasis river blindness — serious adverse effects have been rare, even with repeated doses. Ivermectin is taken as a single dose, which may need to be repeated especially in crusted scabies. The European summary of product characteristics states that transient exacerbation of pruritus may occur at the beginning of treatment, but no frequency for this is given. Ivermectin is unlicensed in the UK and can be supplied from 'special order' manufacturers or specialist importing companies.

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Ivermectin is being studied and tested as a possible treatment of COVID, but its efficacy has not been proven. However, researchers have suggested ivermectin may kill the COVID virus within 48 hours in a petri dish. This data from the lab, although hopeful, would still need to be proven in human studies. It is important to note that the safety and efficacy of ivermectin to treat coronavirus has not been declared by the FDA at this time. S FDA regulates the safety and efficacy of medications sold in U.