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While this medicine has been available for some time it was only recently given TGA approval for treatment of scabies. It is difficult to draw a conclusion regarding the comparative efficacy of ivermectin versus benzyl benzoate due to significant heterogeneity across trials. Ivermectin, when used to treat scabies, is generally well tolerated, with only mild, transient adverse effects. In the RCTs conducted using ivermectin for typical scabies there has been substantial heterogeneity in study methodology, making the clinical efficacy of ivermectin difficult to evaluate. Furthermore there are issues regarding the applicability of the trial population to the proposed PBS population. Potential dosing regimens have been evaluated in cohort and case series studies.

 

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