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The distinct properties of the centrally-acting analgesic tapentadol derive from the combined contributions of an opioid component and a nonopioid component.
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Current strategies to mitigate the opioid crisis and manage chronic pain focus on new products that treat pain effectively with lower potential for abuse and addiction. A Schedule II centrally acting opioid analgesic, tapentadol has two proposed mechanisms of action—mu-opioid agonist activity and norepinephrine reuptake inhibition. Tapentadol modulates pain signals in both ascending and descending neural pathways. Broader post-marketing data sources, including surveillance results from nationwide programs dedicated to studying and preventing addiction, pharmacy and medical claims databases, and online discussion forums have become available over the past decade as well. In addition, intentional exposure rates for tapentadol IR were low, ranging from 0. In addition, when adjusted for drug utilization, rates of tapentadol abuse liability were still lower compared with most opioids but were not the lowest see Figure 2.
Acute and chronic pain is a major problem with repercussion in our society, causing impairment in the quality of life of patients as well as socioeconomic losses, due to work absenteeism. Pain pharmacology: focus on opioids.
The potency of tapentadol is somewhere between that of tramadol and morphine, 7 with an analgesic efficacy comparable to that of oxycodone despite a lower incidence of side effects. Tapentadol is Pregnancy Category C.
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