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Particular care is required when dealing with high doses of opiates. Opiate bioavailability and response are highly variable. Monitor the patient carefully for respiratory depression. This document has been produced with the most current literature available at the time of writing. Consider the need to adjust dose for conditions that increase opiate risk eg elderly, co-morbidities, renal or hepatic impairment. Higher doses sublingually are used for opiate dependence on specialist advice.

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