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Tramadol is a pain medicine similar to an opioid and is classified as a synthetic opioid. It acts in the central nervous system CNS to relieve pain. Tramadol is an FDA-approved medication for pain relief. It has specific indications for moderate to severe pain. Due to possible misuse disorder potential, limitations to its use should be for pain that is refractory to other pain medication, such as non-opioid pain medication. This activity outlines the indications, mechanism of action, methods of administration, important adverse effects, contraindications, toxicity, and monitoring, of tramadol so providers can direct patient therapy where it is indicated as part of the interprofessional team. Dosage should be individualized based on pain severity, therapy response, prior treatment experience and risk factors of addiction, abuse and misuse.

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Tramadol, sold under the brand name Ultram among others, 1 is an opioid pain medication and a serotonin—norepinephrine reuptake inhibitor SNR used to treat moderately severe pain. As is typical of opioids, common side effects include constipation, itchiness, and nausea. Tramadol is used primarily to treat mild to severe pain, both acute and chronic. For severe pain it is less effective than morphine. Pain reducing effects last approximately six hours. The potency of analgesia varies considerably as it depends on an individual's genetics.

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