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Due to the present situation we cannot allow entry to the assessment centre without prior arrangement to protect our vital staff and volunteers. The same consideration is going to be given to our army of home checkers who will not be expected to put themselves or others at risk. Vet checks will be normally be taken up for people wanting to take on a Great Dane and then home checks organised after rehoming until the situation changes. We hope the situation will soon come to an end and you will all keep safe. It is with great sadness we announce that our President Mr Ron Lewis passed away on 1st January age 92 years old. Ron alongside his wife Freda of the famous Walkmyll kennels, played a very active roll in our beloved breed for many years.

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I have to thank students past and present for their inspiration, comments and suggestions over the years and I hope future students and practitioners will benefit from this. Thanks to staff at Wiley, to Neil Manley for creating the index, and to Wendy Mould, who copyedited the book. Finally, thanks to Alex for his understanding and patience. Pharmacology is the science of drugs and their effects on biological systems. A drug can be defined as a chemical that can cause a change in a biological system; the important biological system to be considered in this book is the human body.