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Diazepam may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications.
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Diazepam has a biphasic half-life of about one to three days, and two to seven days for the active metabolite desmethyldiazepam. Diazepam can be administered orally, intravenously must be diluted, as it is painful and damaging to veins, intramuscularly IM, or as a suppository. The elderly are more prone to adverse effects of diazepam, such as confusion, amnesia, ataxia, and hangover effects, as well as falls. Withdrawals can be life-threatening, particularly when excessive doses have been taken for extended periods of time.
This increased chloride ion influx hyperpolarizes the neuron's membrane potential. It is odorless, and has a slightly bitter taste. Common side effects include sleepiness and trouble with coordination. As a result, the arousal of the cortical and limbic systems in the central nervous system is reduced. They are intended for use in buddy aid or self aid administration of the drugs in the field prior to decontamination and delivery of the patient to definitive medical care.
Therapy should be discontinued if any of these signs are noted, although if dependence has developed, therapy must still be discontinued gradually to avoid severe withdrawal symptoms. The antidote for an overdose of diazepam or any other benzodiazepine is flumazenil Anexate. Emesis is contraindicated. Although not usually fatal when taken alone, a diazepam overdose is considered a medical emergency and generally requires the immediate attention of medical personnel.
Dose increases may overcome the effects of tolerance, but tolerance may then develop to the higher dose and adverse effects may increase. Benzodiazepine drugs including diazepam increase the inhibitory processes in the cerebral cortex.
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This continuing care might include prescribing, which would usually be informed by clinical guidelines and be consistent with individual treatment plans, or continuing established treatments by issuing repeat prescriptions, with the authority to adjust the dose or dosage form according to the patients needs. The Review recommended that there should be provision for regular clinical review by the assessing clinician (note: dependent prescriber is now referred to as a supplementary prescriber, Following the Health and Social Care Act to a wider group of health care professions.
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These include receptors in cell membranes or within the cell itself, ion channels and carrier proteins in cell membranes and enzymes in body fluids. Receptors are either an integral protein in the cell membrane or a protein in the cytoplasm or the nucleus.
Authored by Patrick A Devaleria, MD