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Symptoms often manifest themselves six to ten hours after ascent and generally subside in one to two days, but they occasionally develop into the more serious conditions. Symptoms include headache, fatigue, stomach illness, dizziness, and sleep disturbance. Those individuals with the lowest initial partial pressure of end-tidal pCO 2 the lowest concentration of carbon dioxide at the end of the respiratory cycle, a measure of a higher alveolar ventilation and corresponding high oxygen saturation levels tend to have a lower incidence of acute mountain sickness than those with high end-tidal pCO 2 and low oxygen saturation levels. Headaches are the primary symptom used to diagnose altitude sickness, although a headache is also a symptom of dehydration. The most serious symptoms of altitude sickness arise from edema fluid accumulation in the tissues of the body. The physiological cause of altitude-induced edema is not conclusively established.

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