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Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Common side effects include headaches, heartburn, and flushed skin. Sildenafil acts by blocking phosphodiesterase 5 PDE 5, an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. Pfizer originally discovered the medication in while looking for a treatment for angina. The primary indication of sildenafil is treatment of erectile dysfunction inability to sustain a satisfactory erection to complete sexual intercourse. Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; 9 22 these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes.

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My objection with these lists is that they are rarely the result of any original research. The problem is that there is no centralized database of every pedigreed cat worldwide. Rumors abound of just how many cats are regstered over there in another country or different registry. Maine Coons: Especially when overseas data is compiled, the huge popularity of this all American breed is apparent. I would not be surprised that in another couple of decades, the popularity of the Maine Coon overcomes that of the Persian family breeds.

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