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Recurrent airway obstruction RAO is a common respiratory disease of horses characterized by bronchoconstriction, mucus production, and bronchospasm. Pulmonary hypertension is known to occur secondary to recurrent airway obstruction in horses. The development of pulmonary hypertension in RAO-affected horses is well-documented, however, it is not known how rapidly increases in pulmonary artery pressure occur after the onset of RAO. Pulmonary hypertension involves thickening of the pulmonary arteries and an associated increase in blood pressure. While this has been a well-documented finding in humans with severe asthma, until recently, it had not been detected in horses. Severe equine asthma or RAO is characterized by airway inflammation, coughing and labored breathing.