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Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared. Accurately weigh or measure each ingredient. Obtain the required number of sildenafil citrate tablets or the required quantity of powder and place in a mortar. Pulverize the tablets, if used, to a fine powder. Add a small quantity of the Ora-Plus:Ora-Sweet mixture and mix to a smooth paste. Use: Sildenafil citrate oral liquid has been used to treat pediatric pulmonary arterial hypertension in children in whom the risk-benefit profile of sildenafil is deemed acceptable.

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Background: In a previous study, 6-minute walk distance 6MWD improvement with sildenafil was not dose dependent at the 3 doses tested 20, 40, and 80 mg 3 times daily TID. This study assessed whether lower doses were less effective than the viagra 50 mg 1mg mg TID dosage. Hemodynamics, functional class, and biomarkers were assessed. Results: The study was prematurely terminated for non-safety reasons, with of planned patients treated. At week 24, 6MWD increases from baseline were larger in those initially randomized to 20 versus 5 or 1 mg 74 vs 50 and 47 m, respectively.