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Sildenafil is an oral therapy for erectile dysfunction of a broad range of causes. By selectively inhibiting phosphodiesterase type 5, it allows corpus cavernosum smooth muscle to relax, potentiating erections during sexual stimulation. Blood pressure is reduced transiently by sildenafil, but more marked hypotension may occur during concurrent administration of sildenafil and organic nitrates; this combination is contraindicated. Sildenafil is rapidly absorbed, with dose-proportional peak plasma concentrations within 1 hour of administration. The elimination half-life is 3 to 5 hours.
When PDE5 is suppressed, blood is able to flow more freely through the body—including to the you guessed it penis. Individual results will vary. Your medical provider can help you mitigate or treat these symptoms if you experience them. Generic medications do not compromise the safety of a medication. The cost is lower than brand name medication for many reasons, most notably because the brand name medication is no longer legally protected against competition from other manufacturers.
Sildenafil generic Viagra is an erectile dysfunction treatment. It is a cost-effective option and well tolerated by most men. Sildenafil tablets take around minutes to work and lasts for up to 4 hours. Sildenafil is an erectile dysfunction treatment that belongs to the class of drugs known as PDE5 inhibitors. Sildenafil helps men who suffer from erectile dysfunction to achieve and maintain an erection.
Methods and materials: patients with complaints of erectile dysfunction and who completed radiation at least 6 months before the study were approached by mail. They received during 2 weeks 50 mg of sildenafil or placebo; at Week 2 the dose was increased to mg in case of unsatisfactory erectile response. At Week 6, patients crossed over to the alternative treatment. Results: Mean age was 68 years. All patients completed the study.
Sildenafil, a selective inhibitor of cyclic guanosine monophosphate cGMP -specific phosphodiesterase type 5 PDE5, is a well-tolerated and highly effective treatment for erectile dysfunction. The mechanism of action of sildenafil depends on activation of the nitric oxide NO -cGMP pathway during sexual stimulation, which results in corpus cavernosal smooth muscle relaxation and penile erection. Endogenously derived NO is also involved in blood pressure regulation through its effect on basal vascular tone, which is mediated by cGMP levels. Organic nitrates and NO donors exert their therapeutic effects on blood pressure and vascular smooth muscle by the same mechanism as endogenous NO. Since both sildenafil and organic nitrates exert their pharmacologic effects via increases in cGMP concentrations, a double-blind, placebo-controlled, crossover study was undertaken to investigate the effects of sildenafil coadministered with glyceryl trinitrate on blood pressure and heart rate in healthy male subjects. The hemodynamic effects of sildenafil were also evaluated in a second placebo-controlled crossover study in men with hypertension who were taking the calcium antagonist amlodipine, which has a mechanism of action that does not involve the cGMP pathway.
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Sildenafil Brand names: Viagra, Revatio, Caverta, Penegra is generally prescribed to treat men with erection problems. It is also used to treat pulmonary arterial hypertension PAH i. Sildenafil works on erection problems by increasing blood flow to the penis. Purchasing higher quantities usually means lower prices. S FDA regulates the safety and efficacy of medications sold in U.
Viagra is a commonly used medication to treat erectile dysfunction. We break down the prices of the different brands and the available purchasing options. Viagra, otherwise known by its generic name sildenafil, is the best-known medication for treating erectile dysfunction ED. It was the first oral treatment approved to treat ED in the United States. ED affects as many as 30 million men, according to the Urology Care Foundation.