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To determine whether bosentan decreases the plasma concentration of sildenafil in patients with pulmonary arterial hypertension. The ratio of AUC on bosentan treatment relative to that of visit 1 was 0. Bosentan significantly decreases the plasma concentration of sildenafil when coadministered to patients with pulmonary hypertension. Pulmonary hypertension encompasses a group of vascular diseases that result in elevated pulmonary artery pressure, leading to progressive hypertrophy and failure of the right ventricle 1. The treatment options are limited and mortality remains high, particularly in idiopathic pulmonary arterial hypertension PAH and PAH associated with collagen lung disease. A recent advance in the management of PAH has been the introduction of bosentan, an inhibitor of endothelin A and B receptors.
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