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Progesterone Injection may be used alone or with other medications. These are not all the possible side effects of Progesterone Injection. Progesterone injection, a progestin, is a sterile solution of progesterone in a suitable vegetable oil available for intramuscular use. Progesterone occurs as a white or creamy white, crystalline powder. It is odorless and is stable in air. This drug is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer. Progesterone is administered by intramuscular injection.

The pharmaceutical company has decided to discontinue this product. Other preparations of this medicine may still be available. The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Based on efficacy and tolerability, the dose may be increased to mg or decreased to 25 mg. The maximum recommended dose is mg. The maximum recommended dosing frequency is once per day.

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The tablet is white, round, biconvex and 5 mm in diameter. To achieve contraceptive effectiveness, Cerazette must be used as directed see 'How to take Cerazette' and 'How to start Cerazette'. Since the metabolism of steroid hormones might be impaired in patients with severe hepatic disease, the use of Cerazette in these women is not indicated as long as liver function values have not returned to normal see section 4. The safety and efficacy of Cerazette in adolescents below 18 years has not been established. Tablets must be taken every day at about the same time so that the interval between two tablets always is 24 hours. The first tablet should be taken on the first day of menstrual bleeding. Thereafter one tablet each day is to be taken continuously, without taking any notice on possible bleeding. A new blister is started directly the day after the previous one. Tablet-taking has to start on day 1 of the woman's natural cycle day 1 is the first day of her menstrual bleeding.

Letrozole, an aromatase inhibitor, has been demonstrated to be effective as an ovulation induction and controlled ovarian hyperstimulation agent. However, dose administration has generally been limited to 5 days at 2. Results indicate that such doses do indeed offer benefit to patients; in that there is increased follicular growth and a higher number of predicted ovulations with higher doses of the drug. However, increasing doses does not produce a detrimental effect upon endometrial thickness. High-dose letrozole may be of value in women who fail to respond adequately to lower doses. Furthermore, randomized trials are needed to determine whether high-dose letrozole might actually be optimal as a starting dose for certain treatment groups.

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