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Adult 25 mg 3 times a day, increased to 50 mg 3 times a day. When used for Erectile dysfunction: Onset of effect may be delayed if taken with food. M With intravenous use for Pulmonary arterial hypertension: If usual dose not tolerated, consider dose reduction to 10 mg twice daily. Hereditary degenerative retinal disorders; history of non-arteritic anterior ischaemic optic neuropathy; recent history of myocardial infarction; recent history of stroke.

 

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Manufacturer advises reduce dose to 20 mg twice daily with concurrent use of moderate inhibitors of CYP3A4. M See Prescribing in renal impairment. With oral use for Pulmonary arterial hypertension Manufacturer advises reduce dose to 20 mg twice daily with concurrent use of moderate inhibitors of CYP3A4. Manufacturer advises reduce dose to 10 mg once daily with concurrent use of some potent inhibitors of CYP3A4 avoid with ketoconazole, itraconazole and ritonavir.

 

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