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Common side effects include headaches, heartburn, and flushed skin. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; 19 20 these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. Food and Drug Administration FDA found that sildenafil could lead to vision impairment in rare cases, 23 and a number of studies have linked sildenafil use with non-arteritic anterior ischemic optic neuropathy. Sildenafil compound UK, was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent, research facility in England. The first clinical trials were conducted in Morriston Hospital in Swansea. While the sale remains subject to a consultation with a pharmacist, the other restrictions from the trial have been removed, allowing customers over the age of 18 to purchase an unlimited number of pills 70 The decision was made, in part, to reduce online sales of counterfeit and potentially dangerous erectile dysfunction treatments. In, Pfizer filed a patent covering the substance sildenafil and its use to treat cardiovascular diseases.

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Sildigra mg comes up with an active component of Sildenafil citratemg. The medicine offers treatment in men for Erectile Dysfunction. The medicine provides the ability to achieve or sustain an erection for a longer duration. The prolonged effect of the medicine is provided by the active component -sildenafil. It works to induce engorgement for a proper erection during sensual intercourse to be achieved. Sildenafil citrate works to improve other sensual health functioning in the body.

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It is sometimes known by its generic name sildenafil, and sometimes known by its trade name Viagra. Other brands of the same medicine are also available. Sildenafil works by helping the blood vessels in the penis to relax. This allows more blood to flow in and cause an erection. If you have ED, this can make it easier to get an erection.

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The objectives of this study were to evaluate the efficacy and tolerability of high dose sildenafil as a salvage therapy for patients refractory to the maximum recommended dose of sildenafil. Fifty four fully evaluated patients with chronic erectile failure ED who had previously failed to respond to a home trial of sildenafil mg with erections suitable for sexual intercourse were studied. Each american made generic viagra was treated at home with sildenafil at escalating doses of up to mg until either maximal response or intolerable adverse effects occurred. Erectile function was quantified using the erectile function domain of the International Index of Erectile Function IIEF before treatment, with sildenafil mg and with maximal dose of sildenafil and a global efficacy question after 4 weeks of treatment. The mean age of the study group was Mean IIEF question 3 and 4 scores were 1.

The penis is one of the areas where this enzyme works. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection. Sildenafil is also used in both men and women to treat the price of viagra in usa of pulmonary arterial hypertension.

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