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The objectives of this study were to evaluate the efficacy and tolerability of high dose sildenafil as a salvage therapy for patients refractory to the maximum recommended dose of sildenafil. The mean age of the study group was Mean IIEF question 3 and 4 scores were 1. Erectile dysfunction ED is the inability to achieve and maintain an erection of sufficient rigidity for satisfactory sexual intercourse. Sildenafil citrate Viagra TM, Pfizer, UK, a potent, competitive phosphodiesterase type 5 iso-enzyme PDE-5 inhibitor, is the first oral medication to demonstrate significant and reliable efficacy in most patients with ED. All patients had received focussed sildenafil usage education and had been re-titrated to confirm their non-responder status.
Most of the anovulation is due to polycystic ovary syndrome PCOS 3. Subsequently, the pituitary production of gonadotropins increased, resulting in follicular growth and ovulation 4. Failure to achieve pregnancy despite achieving ovulation after CC treatment is defined as CC failure 2, 4. The anti-oestrogenic effect of CC on the endometrium is an important cause of CC failure 6. Oestrogen is necessary for endometrial development during the follicular phase of the menstrual cycle 7.
Sildenafil is a phosphodiesterase 5 inhibitor widely used for the treatment of pulmonary hypertension in children. Despite limited available safety and efficacy evidence, use of sildenafil continues to increase.
Once taken, do not retake it within 24 hours. Its effectiveness lasts 4 to 5 hours.
Respiratory Research volume 10, Article number: 30 Cite this article. Parameters investigated include survival, histopathology, fibrin deposition, alveolar vascular leakage, right ventricular hypertrophy, and differential mRNA expression in lung and heart tissue.
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