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Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.
Sharpe, Adnan Tufail, Philip D. Here, we adopt tests sensitive to the slowing of the visual response likely to result from the inhibition of PDE6. We measured temporal acuity critical fusion frequency and modulation sensitivity in four subjects before and after the ingestion of a mg dose of Viagra under conditions chosen to isolate the responses of either their short-wavelength-sensitive S- cone photoreceptors or their long- and middle-wavelength-sensitive L- and M- cones. Some of the losses appear to increase with frequency, which is broadly consistent with Viagra interfering with the ability of PDE6 to shorten the time over which the visual system integrates signals as the light level increases. However, others appear to represent a roughly frequency-independent attenuation of the visual signal, which might also be consistent with Viagra lengthening the integration time because it has the effect of increasing the effectiveness of steady background lights, but such changes are also open to other interpretations. Sharpe ; Adnan Tufail ; Philip D.
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Sildenafil, indicated for the treatment generic viagra 88 erectile dysfunction, is a potential co-medication in male patients. This study investigated the safety and tolerability of co-administration of vericiguat and sildenafil in healthy volunteers. Participants received vericiguat 10 mg or placebo once daily for 16 days. Both groups received single doses of sildenafil 25 mg, 50 mg, and mg on days 13— Safety, hemodynamic changes, and pharmacokinetic effects were assessed.
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