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Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death see Warnings, Drug Interactions. Alprazolam extended-release tablets, USP contain alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds. Alprazolam, USP is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH. Each alprazolam extended-release tablet, for oral administration, contains 0. The inactive ingredients are lactose monohydrate, hypromellose, and magnesium stearate. Their exact mechanism of action is unknown. Plasma levels are proportional to the dose given; over the dose range of 0. Using a specific assay methodology, the mean plasma elimination half-life of alprazolam has been found to be about

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