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While there is fairly widespread uptake of PGDs in diagnostic radiography, there is also a wide range of good and suboptimal practice. At a non-medical prescribing conference for radiographers, it was noted that some PGDs intended for use by radiographers were being used by administrative staff. Two examples were offered laxatives and topical anaesthetic cream. In both cases, the administrator was personally responsible for posting out these medicines to the patient, in accordance with a PGD.

 

The importance of this is that highly lipid-soluble drugs, for example benzodiazepines, tend to have prolonged duration of buy upjohn xanax online. Plasma protein concentration also falls with age. This means that for extensively protein bound drugs there will be a greater concentration of free drug than expected. This could lead to increased incidence of side effects. This is the case with pethidine (an analgesic).

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During exercise preload increases and therefore cardiac output increases. Cardiac output also depends on end systolic volume, which in turn depends on afterload. Afterload is a function of total peripheral vascular resistance and blood pressure. If afterload becomes greater, ESV increases and cardiac output is reduced.

Authored by Dr. William M Klein, MD

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