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Those most likely to be abused have a short half-life 10 Table 1 or rapidly cross the blood brain barrier, such as alprazolam. In the United States, diazepam and alprazolam appear to be the most abused benzodi-azepines. This potent benzodiazepine is not approved for use in the United States but is diverted from Latin America or Europe in the illegal drug trade. Benzodiazepines with longer half-lives generally are less likely to be abused, although diazepam—with a half-life of up to hours—is the exception. Opponents blame benzodiazepines for promoting the drug culture and argue that prescribing benzodiazepines promotes drug abuse. Arguments from each perspective are summarized in Table 2.
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Between and, over, Americans have died due to a drug overdose. At its peak in, there were Consequently, opioids became easier to obtain, misuse, and become dependent on, and the cost of these drugs went down. As marijuana becomes legalized for medical and recreational purposes in more states, more individuals are likely to try it for themselves. While most people consider the risk of developing a marijuana addiction to be low, the possibility of a psychological dependence remains, nonetheless. Today, the overall cost of marijuana has risen faster than inflation, though high-grade prices remain stable. The below table is a small snapshot across the country of average costs per ounce of marijuana by state. Because the category of opioids includes so many substances, prices vary widely. Since many people with an opioid dependence get their supply from their doctor, insurance can also inadvertently defray the cost of addiction.
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