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Some children and adults with newly diagnosed celiac disease also have vitamin A deficiency; a gluten-free diet can, but does not always, eliminate this deficiency. Cancer Because of its role in regulating cell growth and differentiation, several studies have examined the association between vitamin A and various types of cancer. Examples are provided below. The study randomized participants to take supplements containing 30 mg beta-carotene plus 25, IU 7, mcg RAE retinyl palmitate or a placebo daily for about 6 years to evaluate the potential effects on lung cancer risk 63.

In this study, 29, male smokers aged 50—69 years who smoked an average of During this period, participants were no longer taking the supplements, but most continued to smoke. No current smokers received the supplements containing beta-carotene. Three other clinical trials have found no relationship between taking vitamin A or beta-carotene supplements and lung cancer incidence or mortality 70. One trial randomized 22, male physicians aged 40—84 years to take 50 mg beta carotene on alternate days or a placebo for 12 years 71.

Another trial randomized 7, women mean age None of the supplements had any significant effect on total cancer incidence or cancer mortality, including from lung cancer. A third trial included 29, healthy men and women aged 40—69 years who were living in Linxian, China, where micronutrient deficiencies are common 73. The study randomized participants to take either a placebo or one of four vitamin and mineral combinations including one providing retinol and zinc and another providing beta carotene, vitamin E, and selenium for 5.

The nutrient doses in the supplements were equivalent to or twice as high as U. Among nonsmokers, beta-carotene and vitamin A supplements do not appear to affect the risk of cancer. Because of the role of oxidative stress in AMD pathophysiology, supplements containing carotenoids with antioxidant functions, such as beta-carotene, lutein, and zeaxanthin, might be useful for preventing or treating this condition. Lutein and zeaxanthin which are not precursors of vitamin A, in particular, accumulate in the retina, the tissue in the eye that is damaged by AMD.

Participants in the two highest quintiles of intakes for vitamin A, beta-carotene, or lutein and zeaxanthin had a lower risk of progression to late AMD. This finding confirmed the benefit of replacing beta-carotene with lutein and zeaxanthin. Measles In, measles was responsible for more than, deaths around the world, mostly in young children in low-income countries 77. A major risk factor for severe measles is vitamin A insufficiency.

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