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Osmotic laxatives are salts that act osmotically by retaining the water they are given with, or by drawing water into the bowel from the body. This accelerates transfer of gut contents through the small intestine with an abnormally large volume entering the colon.
It is possible to predict, and to some extent avoid, likely adverse effects in particular populations using knowledge of factors that affect the four processes above in different patient groups. The elderly are known to suffer a higher frequency of adverse effects to medication and the reasons are many and varied. Knowledge of the possible reasons, together with consideration of the problems and changes caused by the ageing process, means that many of the adverse affects could be avoided or at least reduced in intensity. The lower the TR of a drug, the more important these considerations become. Drug absorption can be altered in older people for a number of reasons.
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Mood disorders are associated with changes in regional brain function, which is different to those seen in non-depressed patients who feel sad. Newer techniques have allowed measurement of volume and size of discrete areas of the brain. Atrophy of the hippocampus (a part of the limbic system) is seen in depression possibly through neurodegeneration.
Authored by Dr. Frederick Wenck, DDS