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This application is a nonprovisional application of provisional application Ser. Azithromycin is an antibiotic which is administered orally or intravenously, to treat various infections, particularly infections of the urinary tract, bronchial tract, lungs, sinuses and the middle ear. Oral dosing of azithromycin can result in adverse gastrointestinal GI side effects such as nausea, cramping, diarrhea and vomiting in a significant number of patients. Such GI side effects can also occur in non-human mammals, e. In combined clinical studies of azithromycin involving 3, human patients all dose levels combined, 9. The frequency of these adverse effects increase with higher dose levels of azithromycin. Antacids, which are alkalizing agents that are provided in large doses to raise stomach pH from about 1—3 to about 4—7, may provide a patient with relief from diarrhea, cramping, and gastric upset. Further, to avoid antacid caused interference with azithromycin absorption, patients have also been advised to separate the administration of azithromycin and antacid doses by at least two hours. The present invention further relates to an oral suspension comprising azithromycin, an effective amount of an alkalizing agent and a vehicle. More preferably, the multiparticulates comprise azithromycin, a mixture of glyceryl mono-, di- and tribehenates, and a poloxamer.
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