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The authors have indicated no financial conflicts of interest. To determine the effects of the nonbenzodiazepine sedative zopiclone on the threshold to arousal with zopiclone tablets 7.5 mg online respiratory effort and genioglossus muscle activity and to examine potential physiological factors mediating disparate effects of zopiclone on obstructive sleep apnea OSA severity between patients. The respiratory arousal threshold epiglottic pressure immediately prior to arousal during naturally occurring respiratory events, genioglossus activity and its responsiveness to pharyngeal pressure during respiratory events, and markers of OSA severity were compared between conditions. There was substantial interindividual variability in the changes in OSA severity with zopiclone explained, at least in part, by differences in pathophysiological characteristics including body mass index, arousal threshold, and genioglossus movement patterns.

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These substances are referred to under the Regulation as prescribed restricted substances, and are also more commonly referred to as Schedule 4 Appendix D S4D medicines. A person for whom the S4D medicine has been lawfully prescribed or supplied, or their carer, may also be in possession of the medicine. A licensed wholesaler may possess and supply S4D medicines to authorised entities in accordance with the conditions attached to the licence. A carrier may also be in possession of a S4D medicine for the purpose of delivering it to the addressee.

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