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Zopiclone is a type of sleeping pill that can be taken to treat bad bouts of insomnia. Zopiclone comes as buys blue zopiclone. It also comes as a liquid for people who find it hard to swallow tablets, but this has to be ordered specially by your doctor. The usual dose is to take a 7. It takes around 1 hour to work.

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Absorption is the same in men and women and is not affected by simultaneous ingestion of food or repetition of doses. Zopiclone is swiftly distributed from the vascular compartment. Their apparent half-life times are approximately 4. In animals, no enzyme induction has been observed even at high doses. The low renal clearance of zopiclone on average 8. In various trials with elderly patients, no accumulation of zopiclone was observed in the plasma after repeated doses, in spite of a slight reduction in the hepatic function and extension of the eliminated half-life to approximately 7 hours.

In renal insufficiency, no accumulation of zopiclone or its metabolites have been detected after prolonged administration. Zopiclone crosses the dialysing membrane. For this reason the dosage should be adjusted for these patients. Hepatotoxic effects were observed in repeat dose toxicity studies conducted in rats and dogs. In dogs, anaemia was observed in some studies. Increased incidence of mammary carcinomas in female rats at high multiples of the maximum plasma concentration from therapeutic doses in humans has been attributed to increased beta-estradiol serum levels.

Increased incidence of thyroid tumours in rats has been associated with increased TSH serum levels. In humans zopiclone has no effects on thyroid hormones. Fertility was not impaired in rabbits, in rats impairment of fertility was seen in 2 studies. Foetal developmental retardations and foetotoxic effects in rats and rabbits were observed only at doses well above the maximum human dosage. There was no evidence of a teratogenic potential. Continue typing to refine.

Active ingredient zopiclone. Qualitative and quantitative composition 3. Pharmacological properties 5. Pharmaceutical particulars 6. Marketing authorisation holder 8. Marketing authorisation number s 9. Date of revision of the text. Each film-coated tablet contains 3. Excipients with known effect Each film-coated tablet contains For the full list of excipients, see section 6. Blue, film-coated, round tablet, 'ZE3' on one side and 'G' on the reverse.

Zopiclone is indicated for the short-term treatment of insomnia in adults.

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