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The decision to supply the specific treatment and quantity requested will be based on whether our medical team are satisfied that it will be safe, appropriate, and effective. Aciclovir cream contains the antiviral, aciclovir. It destroys the herpes simplex virus that is responsible for causing cold sores to appear around the lips and face. If the cold sore outbreak is caught early, at the 'tingle' phase, Aciclovir cream can sometimes prevent the cold sore from coming out. In most cases, it can help a cold sore to heal within 4 - 5 days.