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Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Bupropion acts as a norepinephrine—dopamine reuptake inhibitor and a nicotinic receptor antagonist. Bupropion was invented by Nariman Mehta, who worked at Burroughs Wellcome, in Bupropion has several features that distinguish it from other antidepressants: for instance, unlike the majority of antidepressants, it does not usually cause sexual dysfunction, and the occurrence of sexual side effects is not different from placebo. With time, however, this effect becomes negligible.
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