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Bupropion was introduced to the UK market in June Bupropion selectively inhibits the neuronal reuptake of catecholamines norepinephrine and dopamine whilst having minimal effect on serotonin reuptake. The mechanism of action by which bupropion aids smoking cessation is unclear. A smoking cessation programme using bupropion involves starting treatment whilst the patient is still smoking, preferably two weeks before a target stop date. In turn, bupropion and hydroxybupropion both inhibit the CYP2D6 isoenzyme debrisoquine hydroxylase.

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