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Stop smoking treatments really help with managing nicotine cravings and other tobacco withdrawal symptoms. If you have tried stop smoking aids before, it's worth trying again because you may need to try a few to find what's right for you. NRTs give you nicotine the addictive substance in cigarettes and tobacco without any of the harmful chemicals. They can help reduce the withdrawal symptoms of quitting. NRTs have been widely used for many years as a safe treatment to help with quitting. They may also be prescribed by a doctor or a stop smoking service.

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Cigarette smoking remains the largest preventable cause of premature death in developed countries. Bupropion, the first non-nicotine based drug for smoking cessation was licensed in the United States of America US in and in the United Kingdom UK in for smoking cessation in people aged 18 years and over. Bupropion exerts its effect primarily through the inhibition of dopamine reuptake into neuronal synaptic vesicles. It is also a weak noradrenalin reuptake inhibitor and has no effect on the serotonin system. Bupropion has proven efficacy for smoking cessation in a number of clinical trials, helping approximately one in five smokers to stop smoking. Up to a half of patients taking bupropion experience side effects, mainly insomnia and a dry mouth, which are closely linked to the nicotine withdrawal syndrome.

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It is recommended that treatment is started while the patient is still smoking and a target stop date set within the first two weeks of treatment with Zyban, preferably in the second week. The initial dose is mg to be taken daily for six days, increasing on day seven to mg twice daily. The maximum single dose must not exceed mg and the maximum total daily dose must not exceed mg. Insomnia is a very common adverse event which can be reduced by avoiding bedtime doses of Zyban provided there is at least 8 hours between doses. Use in patients under 18 years of age is not recommended as the safety and efficacy of Zyban tablets have not been evaluated in these patients.

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