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Common side effects include daytime sleepiness, headache, nausea, and diarrhea. Zolpidem is a nonbenzodiazepine Z drug which acts as a sedative and hypnotic. Zolpidem was approved for medical use in the United States in Zolpidem is labelled for short-term usually about two to six weeks treatment of insomnia at the lowest possible dose. It can be taken if there are at least 4 hours between the time of administration and when the person must be awake. Zolpidem should not be taken by people with obstructive sleep apnea, myasthenia gravis, severe liver disease, respiratory depression ; or by children, or people with psychotic illnesses. It should not be taken by people who are or have been addicted to other substances. Use of zolpidem may impair driving skills with a resultant increased risk of road traffic accidents. This adverse effect is not unique to zolpidem, but also occurs with other hypnotic drugs.

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Ambien is a sleeping drug, which also has an anxiolytic, anticonvulsant, sedative and myorelaxant effect. Ambien contains zolpidem— a drug substance that falls within the group of cyclopyrrolones similar to benzodiazepine derivatives. The use of zolpidem leads to an increased duration of sleep, reduced frequency of night and early awakenings, as well as a sleep quality improvement. During the research, zopiclone reduced the time of the I stage of sleep, extended the II stage of sleep and increased or maintained the period of deep sleep and maintained paradoxical sleep. Ambien is taken orally directly before sleep.

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