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However, it is commonly observed that infants often respond differently to indomethacin treatment with some requiring multiple courses of the drug and subsequently surgical ligation. Objectives: To explore common variables that could be associated with failure of a primary course of indomethacin for PDA in preterm infants. Methods: We examined 83 preterm infants who received intravenous indomethacin for PDA treatment from online indomethacin We identified those who failed primary pharmacotherapy and required subsequent courses or surgical ligation. Results: Of 77 infants analyzed, 36 Univariate analysis revealed that infants with primary indomethacin failure were significantly more preterm, were more likely to be males, did not receive a complete course of antenatal corticosteroids, their mothers had clinical chorioamnionitis and indomethacin dose interruption was documented during clinical care.

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