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Alendronic acid was first described in and approved for medical use in the United States in Alendronate inhibits osteoclast -mediated bone-resorption.
Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. Alendronate sodium is a bisphosphonate that acts as a potent, specific inhibitor of osteoclast-mediated bone resorption. Colecalciferol vitamin D 3 is a secosterol that is the natural precursor of the calcium-regulating hormone calcitriol 1,dihydroxyvitamin D 3. Osteoporosis in Postmenopausal Women: Osteoporosis is characterized by low bone mass that leads to an increased risk of fracture. The diagnosis can be confirmed by the finding of low bone mass, evidence of fracture on x-ray, a history of osteoporotic fracture, or height loss or kyphosis, indicative of vertebral fracture. These changes result in progressive bone loss and lead to osteoporosis in a significant proportion of women over age Fractures, usually of the spine, hip, and wrist, are the common consequences.
Strength This refers to the amount of the active medicinal ingredient e. Benefit Status Open - Drugs which are reimbursed with no criteria or prior approval. Note: a drug may have limitations that restrict usage. Limitations Drugs which are restricted to those individuals who meet the defined restriction requirements. Limitation based on age such as children under 12 years of age. Interchangeable Drug Products Interchangeable drug products means pharmaceutical equivalents or pharmaceutical alternatives that are the therapeutic equivalents of and that have the same route of administration as a reference product.
The possibility that some drugs could cause dementia symptoms or enhance the likelihood of developing this degenerative condition can be profoundly unsettling. Nevertheless, two classes of drugs are markedly linked to a heightened risk of dementia. Drugs tied to dementia include anticholinergics and benzodiazepines. Both the American Geriatrics Society and numerous studies advise against prescribing these medications to seniors whenever possible. This list of drugs linked to dementia includes certain antidepressants, antiparkinsonians, antipsychotics, antiepileptic drugs, and medications for bladder control.
The osteoclasts adhere normally to the bone surface but lack the ruffled border that is indicative of active resorption. Alendronate does not interfere with osteoclast recruitment or attachment, but it does inhibit osteoclast activity. Women treated with Fosamax lost an average of 3 mm in height, compared with women on placebo who lost an average of 4. Prevention of bone loss was demonstrated in two double-blind, placebo-controlled studies of postmenopausal women years of age. All patients in the trial had either a BMD T-score less than or equal to -2 at the femoral neck and less than or equal to -1 at the lumbar spine, or a baseline osteoporotic fracture and a BMD T-score less than or equal to -1 at the femoral neck.
However, your pharmacist may have suggested a different schedule that is more appropriate for you. Take it regularly and continuously to maintain its beneficial effects. Because it may cause esophageal irritation, this product must be swallowed with a large glass of water. Avoid lying down for at least 30 minutes after taking it. It is not advisable to split, chew or crush this medication since it may irritate your mouth and gastrointestinal tract. Do not use more of this product, or more often, than prescribed.
Your medication may look different. If you have questions, ask your pharmacist. Generic name: Alendronate - oral. Pronunciation a-LEN-droe-nate. Alendronate is used to prevent and treat certain types of bone loss osteoporosis in adults.
It functions by preventing resorption of bone Label 1. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance Label. Alendronic acid tablets have a very low oral bioavialability Label 2. After administration it distributes into soft tissue and bone or is excreted in the urine Label.
USES: Alendronate is used to prevent and treat certain types of bone loss osteoporosis in adults. This medication is taken once per week.
FOSAMAX alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclastmediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.
Bisphosphonates are the most common family of drugs used to treat osteoporosis. They are part of the group of osteoporosis medications known as anti-resorptives.
Alendronate is available as a generic drug or under the brand fosamax 5 mg tablets Binosto and Fosamax. Alendronate works by slowing bone loss and increasing bone mineral density. We make it easy to take part. Alendronate is a medication used mainly to treat osteoporosis weakening of the bones in postmenopausal women. Alendronate works by slowing down bone loss and helping to rebuild bones. Alendronate comes in a tablet, effervescent tablet to dissolve in water, or an oral solution.
If you have certain conditions that cause weak bones, your doctor might suggest Fosamax alendronate as a treatment option for you. But when using Fosamax, always take the dosage that your doctor prescribes. Fosamax contains the active drug alendronate. Fosamax contains the active drug alendronate, which is available as a generic medication. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.