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There is growing interest in the pharmacological treatment of obesity. Before, there were few weight loss medications approved by the FDA. The advent of Glucagon-like peptide-1 receptor agonists GLP-1 receptor agonists, with brand names like Wegovy and Ozempic, has attracted explosive media attention. It is not always easy to determine which medication is right for a particular individual. The market is also rapidly changing, so it is important to keep pace with the available options and their pros and cons. Some weight loss medications have been on the market for many years, and new ones emerge frequently. Commonly prescribed weight loss medications include

Bupropion is efficacious as an antidepressant because of its effects on nicotinic receptors, it is also used to promote smoking cessation. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Shipping and Billing Addresses. Antibody Production and Purification Reagents and Kits. Bovine Secondary Antibodies.

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Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. When used as an aid to smoking cessation, bupropion is thought to confer its anti-craving and anti-withdrawal effects by inhibiting dopamine reuptake, which is thought to be involved in the reward pathways associated with nicotine, and through the antagonism of the nicotinic acetylcholinergic receptor. Bupropion is sometimes used as an add-on agent to first-line treatments of depression such as selective serotonin reuptake inhibitor SSRI medications when there is a treatment-failure or only partial response. This includes the hypothalamus, which is involved in appetite regulation, and the mesolimbic dopamine circuit, which is involved in reward pathways. Bupropion is indicated for the treatment of major depressive disorder MDD, seasonal affective disorder SAD, and as an aid to smoking cessation. Bupropion is also used off-label as a first-line treatment in patients with ADHD and comorbid bipolar disorder when used as an adjunct to mood stabilizers.

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